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Mechanistically, the peptide perturbs the FOXO4 interaction with p53, which selectively causes p53 nuclear exclusion and cell-intrinsic apoptosis (Figure 2, this novel senolytic did remove cells from the PDL9 chondrocytes, which was accompanied by significantly reduced levels of SA--gal staining

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On the other hand, if we think about mechanical denaturation and a whey protein shake foaming like champagne after undergoing a vigorous shaking

2024;doi:10.1038/s41591-024-03015-5

Yao PJ, Eren E, Goetzl EJ, Kapogiannis D

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