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The International Citicoline Trial on acUte Stroke (ICTUS) is a multicenter and double-blind study that assessed the effect of supplementing 2,298 patients with acute ischemic stroke with citicoline (2,000 mg/day) or a placebo for six weeks on several functional and neurologic outcomes and on mortality rate (94)
The peptide undergoes rapid first-pass metabolism when absorbed, which is why bioavailability varies significantly by administration route
Sobos patients often achieve more predictable outcomes and sustained symptom relief over time
The study received approval from the ethics review board of the Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (protocol #2022-4415)
Dosage and sticking to it make a difference
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