Int J Obes 49 , 20052010 (2025)
Titration Schedules Many GLP-1 agonists require a gradual dose escalation, known as titration, to help minimize gastrointestinal side effects like nausea and vomiting
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GLP-1 receptor stimulation triggers pathways through: Phosphoinositol-3 kinase/AKT serine/threonine kinase (PI3K/Akt) Mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) [6] These pathways control cell growth and proliferation, and DPP-IV plays a vital role in thyroid malignancy progression [3]
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