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Diagnostic features include symmetrical presentation, negative Stemmer's sign (ability to pinch skin at the base of the toes), and absence of pitting edema

The PlexusDx Precision Peptide Genetic Test examines predispositions in key peptide-response pathwaysincluding GLP1R rs6923761 and GIPR rs1800437 variants

Ongoing monitoring differs by platform

Tirzepatide is a dual GLP-1/GIP agonist, already FDA- and EMA-approved for type 2 diabetes (Mounjaro) and obesity (Zepbound)

The side effects of these drugs are not fully known, particularly longer-term ones, another reason payers may delay their decision-making process as regards to the current weight-loss drugs, Rayburg said

Declarations Acknowledgement None