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2016 Dec;55(8):2357-2364

Bitter Orange Extract: P-Synephrine Synephrine, also known as p-synephrine or oxedrine, is a natural alkaloid (phenethylamine alkaloid) present in extracts of bitter orange (also called Seville orange, sour orange or Citrus aurantium L.) and other citrus species, which It is widely used for weight loss or weight loss, sports performance, appetite control, energy and mental focus and cognition

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Most available data comes from animal models and preclinical studies

These failures may be traced to the use of inappropriate biomarkers as guides to treatment development