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If a dose is missed, the patient should contact their healthcare provider for advice rather than doubling up doses

Mutations in ASH1L disrupt the expression of the NTRK2 gene that encodes the TrkB receptor, leading to impaired neurite outgrowth and synaptic deficits associated with ASD [149]

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These polymers are ionic and acidic

Therefore, there is still the need for the discovery and/or development of a drug candidate characterized by at least a comparable pain-relieving effect to opioids but with a much better safety profile in terms of expected adverse reactions