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In both cases, different forms of regulatory interaction including Scientific Advice may occur in advance or in parallel to the FIH trial, to agree on the development plan, study design or specific aspects of the investigational compound

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doi: 10.1016/j.jhep.2019.10.003 6 Amini KhiabaniS.AsgharzadehM.Samadi KafilH

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Research data shows the dual-receptor approach generates a larger GH pulse amplitude than GHRH-only stimulation, making it a different research tool for studying secretagogue synergy rather than isolated GHRH signaling

This is may be a problem with some drugs that pass with difficulty or require piggy-back, nano- or viral technologies