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Inhibition of SGLT2 reduces sodium reabsorption in the proximal tubule and enhances Na + delivery to the macula densa, promoting finally the TGF activation with consequent afferent arteriole vasoconstriction and reduction of the single-nephron-glomerular-filtration-rate ( Figure 1 )

Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin

Phospholipid hydroperoxide glutathione peroxidase (PHGPx) in rat testis nuclei is bound to chromatin

DPR, degraded porphyrin

Supplements are administered directly into the bloodstream, making nutrients available for immediate use

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