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In addition, histological analysis revealed a significant difference in liver damage between female and male L-DKO mice (Fig

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Early virological response, on-treatment virological response, sustained virological response, and relapse were defined on the basis of Roche COBAS Amplicor PCR results in accordance with standard definitions.[2] Briefly, early virological response (EVR) was defined as at least a 2 log10 decline in HCV RNA levels or the absence of HCV RNA by the PCR test in treatment week 12