The most practical ceiling for self-directed use is conservative: start near 1,000 mg/day, judge tolerance, and avoid assuming higher doses create better results
Patients typically report decreased cravings and compulsive behaviors within 2-4 weeks
This evidence supports the roles of ghrelin mimetics in boosting hunger (helpful in calorie-surplus phases), activating the GH/IGF-1 axis, and potentially helping maintain or increase lean mass through anabolic signaling
Chronic inflammation and the hallmarks of aging
Nausea, vomiting, diarrhea, and constipation are frequently reported, especially during initial dose escalation phases
In addition, some side effects of glycine that have been reported in certain instances include: soft stools mild sedations stomach discomfort nausea vomiting diarrhea Its not known if giving glycine supplements to children, pregnant or breastfeeding women or people with kidney or liver disease is safe or likely to cause side effects