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In hyperammonemia associated with urea cycle disorders, treatment with hemodialysis can reverse encephalopathy and prevent brain edema and death [36]

However, the evidence for meaningful clinical benefit in elderly populations remains preliminary, and the risk-benefit calculation must account for potential effects on glucose metabolism and cancer risk

Pricing context for authorized products The advisory comes as authorized GLP-1 pricing in Canada continues to shift

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MTHFR variants affect folate metabolism, which interconnects with B12-dependent methylation

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