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48 In contrast, the STEP trials used treatment policy estimands in the primary analyses, which assess all participants who were randomly assigned to treatment regardless of adherence to treatment and regardless of initiation of other therapies

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Among patients who stopped taking tirzepatide, 31.0% doubled their weight loss after two years, 15.2% lost some additional weight, and 9.0% maintained their initial loss, with 55.2% in total maintaining or losing more weight