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doi: 10.3389/fmicb.2019.00751 90 RezendeJ.ZivanovicM.Costa De NovaesM

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Glutamate-cysteine ligase (GCL) forms -glutamylcysteine from glutamate and cysteine, after which glutathione synthetase adds glycine

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When used in combination, NAC and cisplatin may enhance the cytotoxic effects on cancer cells while simultaneously protecting normal cells by mitigating oxidative damage [516, 517], and the combination can also reduce side effects such as ototoxicity caused by cisplatin administration [518]