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Additionally, vitamin B12 deficiency can cause neurocognitive manifestations including depression, episodes of psychosis, delirium, dementia, poor memory performance, and cognitive impairment ( In 1978, Carney and Sheffield found that 31% of patients suffering from depression had low serum vitamin B12 levels (65)

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The World Health Federation (WHF) reported a mortality of 12.1 million from 1990 to 20.5 million in 2021