PIONEER 1 demonstrated that Rybelsus 14 mg reduced A1C by 1.4% versus placebo over 26 weeks, with body weight reductions of 2.3-2.6 kg
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Tirzepatide (Mounjaro, Zepbound) is an FDA-approved medication for type 2 diabetes and chronic weight management that commonly causes gastrointestinal side effects
In the -cell, PC1/3 is up-regulated, resulting in increased processing of proglucagon to GLP-1 while DPP-4 is down-regulated in order to reduce degradation and enhance local intact GLP-1 concentrations
Limited observational data and case reports suggest that GLP-1 receptor agonists do not adversely affect thyroid function in patients with pre-existing hypothyroidism who are maintained on stable levothyroxine therapy
32,33 As IBD often begins in youth, it may hinder peak bone mass acquisition and elevate adult fracture risk