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However, supplementation may bring some side effects

In humans, clinical data remain limited, but anecdotal reports and early safety studies suggest benefits in soft-tissue recovery and gastrointestinal health

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Another research including 111 families, demonstrated that deficient MTHFR enzyme activity in pregnant women was related to the A1298C variant, which was associated with a higher risk of schizophrenia in the offsprings 60

Treatment was generally well tolerated and safe