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Because of the increased risk of adverse reactions, it is not recommended for use in the absence of diabetes

For example, the mutant presenilin 1, one of the main causes of familial AD, was found to cause a dysfunction in lysosomal acidification, leading to elevated lysosomal pH values 125 , lysosomal proteolysis injury, and AD-like pathologic alterations 126

however, EAS enzymes are deactivated due to chronic elevated H 2 O 2 induced by defective mitochondria (Schallreuter, 2014)

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This is exactly what my original hormone doc told me