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While these medications offer significant benefits, they can also lead to gastrointestinal side effects, including nausea, vomiting, and constipation

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Caution is also needed in those with severe gastrointestinal disease, a history of pancreatitis, or significant psychiatric comorbidity requiring specialist input

Regular checkups with doctors are important to monitor side effects and how your body reacts

The PDZK1 gene, located in another locus associated with elevated serum urate, is expressed in the kidney and encodes a product containing the PDZ domain, which acts as a scaffolding protein for a variety of subcellular transport proteins, potentially contributing to the regulation of urate levels within the body

SIDE EFFECTS Many people experience no side effects while taking zonisamide