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A mixture of polyphenols composed of epigallocatechin, gallate, catechin, tannic acid, and querectin when injected at intra-articular region of rat model of RA, prevented cartilage destruction while reducing inflammation (117)

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PDRN is too large to passively cross intact stratum corneum, which is why it benefits significantly from microinfusion delivery

(PubMed) Herbst RA, Uter W, Pirker C, Geier J, Frosch PJ

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