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Schwaitzberg 2017

The major uses for CA inhibitors include the treatment of glaucoma, the treatment of metabolic alkalosis due to hypokalemia or high aldosterone levels, alkalizing urine to enhance uric acid and cystine secretion in order to prevent renal calculi, and in the treatment of acute mountain (high altitude) sickness

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It has been hypothesised that stimulation of melanin production may be a protective reaction of the oral mucosa, associated with detoxification of polycyclic amines and benzopyrenes, thus being a side effect of tobacco use [30]

A small percentage experience persistent mild nausea, which often resolves during the next dose escalation phase or within 2 to 3 weeks of continued therapy

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