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Similar content being viewed by others Introduction Malignant melanoma of the skin (CMM) is one of the fastest increasing cancers in incidence 1,2

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Further quantum mechanics/molecular mechanics (QM/MM) calculations showed that the trisulfide cofactor lowers the energy barrier for nucleophilic attack by H 2 S by 6.3 kcal/mol, increasing catalytic efficiency by approximately 105-fold

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