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Cowan et al., 2+ imaging has demonstrated that synaptically induced rises of [Ca 2+ ] i in aspiny dendrites do not spread much but are kept local by interneuron-specific mechanisms (Goldberg et al., Box 1 and below in the sections on calcium signals and heterosynaptic plasticity

Studies also raised important questions about the long-term value and sustainability, particularly when these drugs can cost more than $1,000 per month

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