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In the context of MTHFR variants, providing the body with methylfolate will help counter its own, reduced production of methylfolate

Thus the best-known "function" of B 12 (that which is involved with DNA synthesis, cell division, and anemia) is a facultative function that is mediated by B 12 -conservation of an active form of folate which is needed for efficient DNA production

Here are some case studies: Case Study 1: A 67-year-old woman was diagnosed with pernicious anaemia and started on vitamin B12 and folate therapy

Clinical trials show average weight loss of 24.2% of body weight at standard doses over 48 weeks

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Older people are susceptible to deficiency because they do not produce enough hydrochloric acid in their stomachs to absorb the Vitamin B12 in the food they eat