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Symptoms & causes
TafazoliS.Mechanisms of drug-induced oxidative stress in the hepatocyte inflammation model,Doctor of Philosophy, Department of Pharmaceutical Sciences, University of Toronto,2008 27
Our study has important implications for our understanding of enzymatically active and inactive glutaredoxins and could be useful for the design and optimization of artificial glutaredoxins, glutaredoxin-coupled fluorescent redox sensors and transition-state inhibitors
However, their clinical translation is impeded by their low bioavailability, poor stability, and inability to cross the BBB 25
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