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When DCA accumulates excessively in the intestine, it may cause damage to the mucosal barrier, abnormal immune activation, and microbial dysbiosis, ultimately inducing or exacerbating colitis progression (156)
Activated neutrophils secrete myeloperoxidase (MPO), neutrophil elastase (NE), protease 3, histamine and matrix metalloproteinase 9 (MMP-9), all of which increase OxS, promote liver injury and the proliferation of hepatic stellate cells (HSCs), thereby increasing liver fibrosis 123,124
Prog Neuropsychopharmacol Biol Psychiatry 2012;39:2807
Renal glucose reabsorption inhibitors to treat diabetes
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