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GIP suppresses macrophage-dependent inflammation, whereas GLP1 reduces gut inflammation through its receptor on intraepithelial lymphocytes

Newer GLP-1 RAs like semaglutide are copied after the human GLP-1 form

Liepelt I, Reimold M, Maetzler W, Godau J, Reischl G, Gaenslen A, et al

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However, the current trial data with retatrutide suggest that these theoretical risks have not translated into clinical problems

The company offers both semaglutide and tirzepatide in multiple delivery formats with publicly listed pricing on its website