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Exendin-4 (Ex-4), another GLP-1RA that is homologous to commercially available exenatide, ameliorated IR in primary neurons through insulin receptor substrate-1 (IRS-1), AKT, and glycogen synthase kinase-3 (GSK-3) pathways

This important question is addressed in the recent 2026 review Why Do Weight Loss Drugs Fall Short in Diabetic Patients

If you are lean with less subcutaneous tissue, use a 45-degree angle to reduce the chance of hitting muscle

If side effects are going to happen, the first (and maybe second) shot tends to be the hardest

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

Vendrell et al., 2011