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K.ShinM.et al

High doses can lead to systemic spillover, desensitization, and increased side effects like hypoglycemia or swelling

doi: 10.1016/j.phrs.2021.105874

Risks, side effects and interactions Very high doses (more than seven grams) of L-cystine can be toxic to human cells, so its important to keep track of your doses and take NAC under the guidance of your healthcare provider, especially if you take it to treat chronic conditions