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Treatment with melatonin has been shown to activate the Ras-Raf-MAPK signaling pathway and enhance the cellular stress response, and promote the death of cancer cells under sustained stress conditions [174, 175]

TB-500 is a synthetic fragment of Thymosin Beta-4 (the Ac-LKKTETQ region) linked in preclinical work to cell migration and angiogenesis through G-actin regulation [11] [12]

Anti-diarrhoeal agents such as loperamide may provide short-term symptomatic relief, but should not be used if there is blood in the stool, high fever, or signs of severe dehydration, and are intended for short-term use only

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In contrast, baseline kidney function in our cohort was relatively preserved