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Lipsitz, Ponterio & Comerford has spent decades doing exactly that

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Citation on PubMed Corti S, Bordoni A, Ronchi D, Musumeci O, Aguennouz M, Toscano A, Lamperti C, Bresolin N, Comi GP

doi:10.1093/labmed/lmaa075 89

Higher melasma area severity index may represent higher oxidative stress, the higher oxidative stress condition, and certainly requires more GSH to cope with free radicals, this may be the basis for the finding of lower melasma levels often with the increasing severity of melasma in this study

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