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[5] Jastreboff AM, et al

Initial treatment focuses on IV fluid replacement (typically 1-2 liters of normal saline) while investigating underlying causes through blood tests and cardiac monitoring

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Both selective AMYR agonists, and dual CTR and AMYR agonists such as sCT 5,6,7 , have demonstrated efficacy in controlling appetite and body weight, however this is not seen with a CTR-selective agonist 9

Oral semaglutide has an established safety profile in its approved uses

The intrinsic factor is absorbed in the small intestine (ileum) with calcium