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of this final rule with comment period, we are removing the HCHE measure beginning with the CY 2025 reporting period/CY 2027 payment determination

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This multi-axis neuroendocrine regulatory profile positions DSIP as a broad hypothalamic-pituitary axis modulator, not merely a sleep-specific peptide, and makes it a research tool for studying the neuroendocrine consequences of altered sleep homeostasis and circadian rhythm disruption

We propose staged translation: initial human trials using systemic IV or intranasal delivery, reserving direct CNS approaches for refractory cases

You want every 1mL of liquid to contain 10mg of peptide