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Notable Studies: Efficacy and safety of liraglutide 3.0 mg in patients with overweight and obese with or without diabetes: a systematic review and meta-analysis Efficacy and safety of liraglutide for obesity and people who are overweight: a systematic review and meta-analysis of randomized controlled trials The effectiveness and safety of liraglutide in treating overweight/obese patients with polycystic ovary syndrome: a meta-analysis Also Known As: Victoza, Saxenda, Xultophy, NN2211, GTPL1133 Research Applications: Weight loss Metabolic syndrome PCOS Neuroprotection Risks: Nausea and gastrointestinal upset Injection site reactions Tachycardia Potentially pancreatitis and neoplasias FDA approval limited to T2D and overweight/obese patients Chemical Structure What is Liraglutide

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Int J Environ Res Public Health

226 This implies that GLP-1 can induce alpha-cells to produce GLP-1 via indirect mechanisms

A study of patients with T2MD and congestive heart failure found that their levels of ANP were increased, whereas blood pressure was decreased, indicating that the GLP-1R-ANP axis is only active in patients with congestive heart failure (123)