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A FIH trial commonly begins with a Single Ascending Dose (SAD) phase

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the median t max was 6.0 h in both groups, and the mean t was 20 and 18 h, respectively (Electronic Supplementary Table 2)

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Although other vaccines comprising different antigen targets have been developed, none have proven effective in preventing infections caused by NTHi (Smith-Vaughan et al., 2014)