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At present, several oral antidiabetic medications are used for the treatment of T2DM including, -glucosidases inhibitors, biguanides, sulfonylureas, meglitinides, GLP-1 receptor agonists (GLP-1RAs), peroxisome proliferator-activated receptor (PPAR-) agonists, dipeptidyl peptidase-4 (DPP-4) inhibitors, and sodiumglucose transporter 2 (SGLT2) inhibitors

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Without GPX4 activator, the downstream metabolites of the 5-LOX, 12-LOX, and 15-LOX pathways were markedly elevated after A23187 stimulation ( Figure 4 ), compared to the normal state ( Supplementary Figure S2 )

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