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These medicines mimic the action of naturally occurring GLP-1, a hormone produced in the intestine that plays a crucial role in glucose regulation and appetite control

Practical considerations such as injection frequency, needle size, and gastrointestinal tolerability may also influence individual patient selection

In the ATTAIN-MAINTAIN trial, orforglipron's profile was "consistent with previous orforglipron Phase 3 studies." The most common adverse events were gastrointestinal-related and were generally mild-to-moderate in severity, which is expected for the GLP-1 class

Increasing other fullness hormones , including peptide YY (PYY)

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At M6, mean weight loss was significantly higher in the GLP-1-RA group (12.0% [3.3] vs