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CB4211 Clinical Trial: The Only Human Data (CohBar 2021) CB4211, a MOTS-c analog developed by CohBar, completed Phase 1a/1b clinical trials

Stoll R, Schmidt H, Stern H, Ruppin H, Domschke W

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(1) Dietary pattern adaptation Western populations (Europeans, Australians): the Mediterranean diet (rich in omega-3 and olive oil) reduces depression risk, as their gut microbiota (high Faecalibacterium abundance) efficiently metabolizes omega-3 into anti-inflammatory resolvins (86, 87, 331)

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The incretin effect of GLP-1 is largely due to its direct actions on pancreatic beta and delta cells, but another vagal signaling pathway may exist that enhances incretin effects [33]