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doi: 10.3390/toxics10010036 99 SrivastavaA

Factors affecting the preservation of supplements A dietary supplements stability will vary somewhat depending on its composition or delivery method

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The hepatotoxicity of APAP rests predominantly with the highly toxic and reactive compound NAPQI, which forms covalent bonds with sulfhydryl groups on cysteine and lysine molecules within the mitochondria of hepatocytes and which spontaneously reacts with GSH and binds to hepatic proteins.8,11 The protein adducts formed, specifically those of mitochondrial protein adducts, lead to oxidative injury and hepatocellular necrosis