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PR-independent neurosteroid regulation of 2-GABA-A receptors in the hippocampus subfields

Early trends suggest that co-agonists like tirzepatidewhich combine GLP-1 agonism with additional mechanismsmight offer fewer side effects compared to standalone GLP-1 therapies like MET-097i

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Although the IRE1 inhibitor was inefficient alone, its combination with paclitaxel delayed the time to tumor regrowth after stopping the treatment (Marciniak et al