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Antiosteoporotic and selective estrogen receptor modulator In one study silymarin intake could increase the parathormone concentration in ovariectomized -induced bone loss that had leaded to trabecula thickness of the femur and had a positive effect on bone formation

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166,167 The pathophysiology of diabetic mononeuropathy includes ischemic mechanisms, such as the occlusion of the vasa nervorum leading to nerve infarction, metabolic factors, including hyperglycemia-induced oxidative stress, and the formation of advanced glycation end products, contributing to nerve damage