Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death
This also pinpointed when glutathione is specifically required: during the early steps of metastatic colonization, when cancer cells adapt rapidly to the stressful environment of a new tissue
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References The Lancet (2023) Rosenstock J, et al
Beyond acting as carriers, certain metal-based NPs exhibit intrinsic anti-inflammatory activity and can function as therapeutic agents without encapsulating additional drugs or requiring external stimuli such as heat, magnetic fields, or light [40]
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