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Many immunomodulatory drugs also inhibit TGFB, reduce plasma levels of IL1 and IL1B, and prevent activation of NFkB

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MOTS-c was found to upregulate key genes in the TGF-/Smad pathway (such as TGF-1, TGF-2, and Smad7) and increase the expression of bone formation markers like alkaline phosphatase (ALP), osteocalcin, and Runx2 in bone cells