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10.1016/j.jmbbm.2023.106033 282 SantamaraE.Anjinho de BarrosL.GonzlezC.MaestroA

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[24,43] Our findings suggest that the redox potential of the nucleus and nucleoli is tightly buffered, ensuring that redox-sensitive biochemical pathways operate consistently despite structural and morphological changes during mitosis

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Preclinical studies in Alzheimers mouse models, aged rats, and aged rhesus monkeys showed BDNF gene therapy prevented neuronal death, stimulated synaptic function, and improved memory