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In vitro research found that metformin activated a novel galectin-directed ubiquitin signal transduction system in response to lysosomal membrane damage, induces autophagy, and facilitates the elimination of M.tb from macrophages [117]

Rather than manipulating individual pathways in isolation, effective intervention will likely require coordinated, context-dependent modulation of chaperones, autophagy, UPS activity, and ER stress responses

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doi: 10.1056/NEJMoa042980

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Research indicates that epithalon may influence circadian rhythms, support immune function, and contribute to overall cellular health