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These Grxs can coordinate a Fe 2 S 2 cluster at the interface of a dimer formed by two Grxs, using the two N-terminal active site thiols and the thiols of two non-covalently bound GSH molecules as ligands [21,22]

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When 14C-4-androstenedione was used as substrate (Figure 1), it was metabolised mainly to the diols, testosterone (T), DHT and androstanedione (A)

While NAD therapy shows promise in several areas, we emphasize that more clinical research is needed to fully understand its benefits, risks, and best practices