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Several hundred peer-reviewed studies, the majority in rats, covering tendon, ligament, muscle, gut, vascular, and central nervous system injury models

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We propose that trimetazidine is a promising drug that can be repurposed to target mitochondrial dysfunction, inflammation and oxidative stress to treat bipolar depression

Maintenance dose optimization Once reaching the initial target dose, assessment determines whether further increases benefit the protocol

Sleeplessness is the most common side effect, presented either in the form of having a hard time falling asleep or awakening very early in the morning and not getting back to sleep

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