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Ginsenoside compound K increases glucagon-like peptide-1 release and L-cell abundance in db/db mice through TGR5/YAP signaling

This means retatrutide is currently only available for research purposes through specialized suppliers

N Engl J Med (2019) 381(9):84151

Only very small molecules can reliably pass through the skin, which is why patches work for things like nicotine, certain hormones (like estrogen), or some pain medications