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However, under conditions of stress and inhibition of the electron transport chain, the enzyme works in the opposite direction by transferring electrons from NADPH to NAD + , which impairs mitochondrial antioxidant defenses and feeds more reducing equivalents into the impaired electron transport chain leading to increased electron leakage and superoxide formation [133]

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The precise sequence of these amino acids is Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val