The 12mg-cohort escalation consumes 2 + 2 + 2 + 2 + 4 + 4 + 4 + 4 + 8 + 8 + 8 + 8 + 10 + 10 + 10 + 10 = 96 mg over 16 weeks before reaching peak maintenance dose, meaning two 30mg vials cover the full escalation period, and subsequent maintenance can be planned around a 30mg-vial cadence (2.5 weeks of supply per vial at 12mg/week)
Nauk et al, 2011
Fatigue typically lasts two to four weeks but varies by individual
I find that for people who have the potential to start a family or to continue their family, it's a very high-risk medication, says Fishman, Thus, the FDA recommends that if you are of child-bearing potential, use a highly-effective method of birth control and talk to your doctor now about weaning off the medication if you consider getting pregnant in the near future
Planning your injection timing to avoid peak nausea on a fasting collection morning is a minor but real quality-of-life consideration
Common injection sites in research studies include the abdomen, thigh, or upper arm regions