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Potential side effects include hypoglycemia (low blood sugar), joint discomfort, water retention, and jaw/facial changes with prolonged use

Dosage modifications or discontinuation may be necessary if abnormalities in laboratory parameters are observed

PLoS One 12(11):e0187351 Zmock M, Hofbauer S, Schaffner I, Gasselhuber B, Nicolussi A, Soudi M, Pirker KF, Furtmller PG, Obinger C (2015) Independent evolution of four heme peroxidase superfamilies

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Butyrate, a type of SCFA, serves as an energy source for IECs, improves villus structure, enhances intestinal elasticity, and increases the absorptive surface area, hence promoting calcium absorption

Clausen et al[24] have reported that GSH plays an important role in the opening of the TJ of intestinal epithelia enhancing the paracellular transport